Bromoacetyl bromide
Bromoacetyl bromide
CAS: 598-21-0
Molecular Formula: C2H2Br2O
Bromoacetyl bromide - Names and Identifiers
| Name | Bromoacetyl bromide |
| Synonyms | bromoacetyl BroMoacetyl br Bromoacety bromide bromo-acetylbromid BROMOACETYL BROMIDE Bromoacetyl bromide bromcacetyl bromide acetylbromide,bromo- Acetyl bromide, bromo- BROMOACETIC ACID BROMIDE |
| CAS | 598-21-0 |
| EINECS | 209-923-5 |
| InChI | InChI=1/C2H2Br2O/c3-1-2(4)5/h1H2 |
| InChIKey | LSTRKXWIZZZYAS-UHFFFAOYSA-N |
Bromoacetyl bromide - Physico-chemical Properties
| Molecular Formula | C2H2Br2O |
| Molar Mass | 201.84 |
| Density | 2.324g/mLat 20°C |
| Melting Point | 148.5°C (estimate) |
| Boling Point | 147-150°C(lit.) |
| Flash Point | >105°C |
| Water Solubility | REACTS |
| Vapor Presure | 3.8 mm Hg ( 25 °C) |
| Appearance | Powder |
| Color | White |
| BRN | 605440 |
| Storage Condition | Refrigerator (+4°C) |
| Stability | Stable, but reacts violently with water. Incompatible with water, moisture, alcohols, strong bases, strong oxidizing agents. |
| Sensitive | Moisture Sensitive |
| Refractive Index | n20/D 1.547(lit.) |
| Physical and Chemical Properties | Characteristics of colorless transparent or yellowish liquid. boiling point 147~150 ℃ relative density 2.317 refractive index 1.5475 soluble in benzene, ether, chloroform. |
| Use | Used as a pharmaceutical Intermediate For Organic synthesis |
Bromoacetyl bromide - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | R34 - Causes burns R14 - Reacts violently with water |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S8 - Keep container dry. S30 - Never add water to this product. S25 - Avoid contact with eyes. |
| UN IDs | UN 2513 8/PG 2 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-19 |
| TSCA | Yes |
| HS Code | 29159080 |
| Hazard Class | 8 |
| Packing Group | II |
Bromoacetyl bromide - Nature
Open Data Verified Data
colorless transparent or yellowish liquid. Boiling point 147~150 deg C. The relative density was 2.317. Refractive index 5475. Soluble in benzene, ether, chloroform. Decomposition in water and alcohol, smoke in the air.
Last Update：2024-01-02 23:10:35
Bromoacetyl bromide - Preparation Method
Open Data Verified Data
with glacial acetic acid as raw material, after mixing with red phosphorus, Dropwise adding bromine to half the amount of heating, light, continue to add bromine, feeding, warming up to 140 ℃, after cooling and distillation, a fraction of 146 to 152 ° C. Was collected and obtained.
Last Update：2022-01-01 10:32:17
Bromoacetyl bromide - Use
Open Data Verified Data
It is mainly used as a pharmaceutical intermediate (e. G., a starting material for the anesthetic r carbonyl sodium butyrate).
Last Update：2022-01-01 10:32:17
Bromoacetyl bromide - Safety
Open Data Verified Data
This product is irritant and corrosive. Production equipment should be closed, the workshop should have good ventilation. Operators should wear protective equipment such as goggles, masks, gloves and work clothes.
It should be tightly enclosed in brown glass bottles, and the jacket should be protected by a wooden box. Store in a cool, dry, ventilated place. Sun protection, moisture-proof. Handle irritant substances properly.
Last Update：2022-01-01 10:32:18
Bromoacetyl bromide - Reference Information
| LogP | -0.04 at 25℃ |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Uses | Thiamidine cephalosporin intermediates can also be used as intermediates in other organic or pharmaceutical synthesis. Mainly used as a pharmaceutical intermediate (such as the raw material of the anesthetic sodium γ-carbonyl butyrate). An intermediate of thiamidine cephalosporin. Used as a pharmaceutical intermediate for organic synthesis |
| Production method | It is obtained by the reaction of acetic acid and bromine under the catalysis of phosphorus. Red phosphorus is dried at 105 ℃ for 2 hours, mixed with glacial acetic acid, stirred and added bromine dropwise. When half bromine is added, it is immediately heated and illuminated, and bromine dropwise is continued. After adding, the temperature is raised to 140 ℃ for 2h. Cooling. Distillation, collection of 146-152 degrees C fraction, to obtain the product. |
| category | corroded articles |
| toxicity classification | highly toxic |
| flammability hazard characteristics | non-combustible; decomposed by heat or water toxic and corrosive hydrogen bromide gas |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; Store separately from oxidant. |
| fire extinguishing agent | dry sand, dry stone powder, carbon dioxide; No water |
Last Update：2024-04-09 15:16:46
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